Endoscopic Depth Measurement and Super-Spectral-Resolution Imaging

Intra-operative measurements of tissue shape and multi/ hyperspectral information have the potential to provide surgical guidance and decision making support. We report an optical probe based system to combine sparse hyperspectral measurements and spectrally-encoded structured lighting (SL) for surface measurements. The system provides informative signals for navigation with a surgical interface. By rapidly switching between SL and white light (WL) modes, SL information is combined with structure-from-motion (SfM) from white light images, based on SURF feature detection and Lucas-Kanade (LK) optical flow to provide quasi-dense surface shape reconstruction with known scale in real-time. Furthermore, super-spectral-resolution was realized, whereby the RGB images and sparse hyperspectral data were integrated to recover dense pixel-level hyperspectral stacks, by using convolutional neural networks to upscale the wavelength dimension. Validation and demonstration of this system is reported on ex vivo/in vivo animal/ human experiments.